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Patients receiving transdermal clonidine therapy should be carefully instructed in the use of the transdermal system.Mild, transient abnormalities in liver function test results have occurred in about 1% of patients during oral clonidine therapy.

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Allergic contact sensitization to clonidine has occurred in about 20% of patients with transdermal therapy, most frequently in white females and least frequently in black males; the dermatitis may require discontinuance of transdermal therapy. Although systemic anaphylactic reactions have not been reported to date, subsequent administration of oral clonidine or continued clonidine for pain mechanism of transdermal clonidine to patients who experience allergic reactions with transdermal therapy may result in a recurrence of the reaction or development of a generalized rash, urticaria, or angioedema.Clonidine hydrochloride extended-release tablets can pass into your breast milk.

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