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    During pregnancy, this medication should be used only when clearly needed.Diltiazem does not appear to be removed by peritoneal or hemodialysis. Limited data suggest that plasmapheresis or charcoal hemoperfusion may hasten diltiazem elimination following overdose.

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    Antiarrhythmic action: By impeding the slow inward influx of calcium at the AV node, diltiazem decreases conduction velocity and increases refractory period, thereby decreasing the impulses transmitted to the ventricles in atrial fibrillation or flutter.Events observed following diltiazem overdose included bradycardia, hypotension, heart block, and cardiac failure.

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