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    Oral bioavailability of diltiazem hydrochloride increases disproportionately with increasing doses; as the dosage of extended-release capsules increases from 120 to 240 mg daily 60 to 120 mg twice daily cardizem com bioavailability of the drug approximately triples, as the dosage of conventional tablets or extended-release capsules increases from 240 to 360 mg daily, the oral bioavailability approximately doubles, and as the dosage of extended-release capsules increases from 120 to 540 mg daily, the oral bioavailability of the drug approximately increases sevenfold.

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