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Estradiol
Clinical data
Pronunciation/ ˌ ɛ s t r ə ˈ d aɪ oʊ l / ES -trə- DY -ohl [1] [2]
Trade namesNumerous
AHFS/Drugs.comMonograph
Pregnancy categoryAU: B1 US: X (Contraindicated)
Routes of administration• By mouth (tablet) • Sublingual (tablet) • Intranasal (nasal spray) • Transdermal (patch, gel, cream, emulsion, spray) • Vaginal (tablet, cream, suppository, insert, ring) • IM injection (oil solution) • SC injection (aq. soln.) • Subcutaneous implant
Drug classEstrogen
ATC codeG03CA03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityOral: <5% [3] IM: 100% [4]
Protein binding~98%: [3] [5] • Albumin: 60% • SHBG: 38% • Free: 2%
MetabolismLiver (via hydroxylation, sulfation, glucuronidation)
MetabolitesMajor (90%): [3] • Estrone • Estrone sulfate • Estrone glucuronide • Estradiol glucuronide
Elimination half-lifeOral: 13–20 hours [3] Sublingual: 8–18 hours [6] Transdermal (gel): 37 hours [7] IM (as EV): 4–5 days [4] IM (as EC): 8–10 days [8] IV (as E2): 1–2 hours [4]
ExcretionUrine: 54% [3] Feces: 6% [3]

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