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Diphenhydramine
Clinical data
Pronunciation/ ˌ d aɪ f ɛ n ˈ h aɪ d r ə m iː n /
Trade namesBenadryl, Unisom, Sominex, others
AHFS/Drugs.comMonograph
MedlinePlusa682539
Pregnancy categoryAU: A US: B (No risk in non-human studies)
Dependence liabilityVery low
Routes of administrationBy mouth, intramuscular injection, intravenous, topical, rectal
ATC codeD04AA32 ( WHO ) D04AA33 ( WHO ), R06AA02 ( WHO )
Legal status
Legal statusAU: S2 (Pharmacy only) US: OTC
Pharmacokinetic data
Bioavailability40–60% [2]
Protein binding98–99%
MetabolismLiver (CYP2D6 (80%), CYP3A4 (10%)) [1]
Elimination half-lifeRange: 2.4–13.5 hrs [3] [2] [4]
ExcretionUrine: 94% [5] Feces: 6% [5]

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