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The manufacturer states that the efficacy of fluoxetine beyond 12 weeks of therapy has not been demonstrated in controlled studies.In mice treated with fluoxetine 5 or 20 mg/kg given intraperitoneally for 4 weeks beginning at 4 weeks of age, bone formation was reduced resulting in decreased bone mineral content and density.

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Tricyclic antidepressants, class IC antiarrhythmics is initiated in a patient who is receiving or has received fluoxetine during the previous 5 weeks. Because of the risk of serious low dose prozac for anxiety arrhythmias and sudden death potentially associated with increased plasma concentrations of thioridazine, thioridazine is contraindicated in any patient who is receiving or has received fluoxetine during the previous 5 weeks.Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al.

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