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This dose is 188 times and 30 times the maximum daily human dose based on mg/kg and mg/m2, respectively.

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Do not continue taking the individual medications lisinopril and/or hydrochlorothiazide after you start this medication.If you have diabetes and you're taking insulin, have your responses to therapy monitored closely.

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These effects are angiotensin II antagonists or ACE inhibitors.ACE-inhibitors and angiotensin II receptor blockers should therefore not be used concomitantly in patients with diabetic nephropathy.

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