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Monitor therapy Tacrolimus Systemic Metoclopramide may increase the serum concentration of Tacrolimus Systemic Specifically, treatment of gastroparesis may increase tacrolimus concentrations.ptodate.

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It is also thought to suppress the primary afferent neurons from firing, as well as have anti-inflammatory properties and direct stimulatory effects on smooth muscle.ateman DN, Darling WM, Boys R, Rawlins MD. Extrapyramidal reactions to metoclopramide and prochlorperazine.

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Extrapyramidal disorders were more likely to occur after several doses, although usually early in treatment, and were less likely at slower infusion rates when metoclopramide was given intravenously.

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