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The most common side effects of PROVIGIL are headache, nausea, nervousness, stuffy nose, diarrhea, back pain, anxiety, trouble sleeping, dizziness, and upset stomach. PROVIGIL may cause allergic reactions.Amide hydrolysis is the single most prominent metabolic pathway, with sulfone formation by cytochrome P450 CYP 3A4/5 being next in importance.

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21 The addition of two fluoro-groups paves the way for enhanced bioavailability, which means that a higher percentage of the drug gets absorbed in the digestive tract, thereby permitting intake of smaller doses.Other associated manifestations included myocarditis, hepatitis, liver function test abnormalities, hematological abnormalities e.

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