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Pharmacotherapeutic group: Lipid modifying agents, HMG-CoA-reductase inhibitors, ATC code: C10AA05 Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. Download - International Diabetes Federation If muscular symptoms are severe and cause daily discomfort, even if the CK levels are elevated to 5 x ULN, treatment discontinuation should be considered.

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    Yslipidemia. 0Peripheral vascular disease.Based on the data available, the frequency, type and severity of adverse reactions in children is similar to adults. Exceptional cases of interstitial lung disease, especially with long term therapy see section 4.

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    Atorvastatin was the safest statin in relation to renal function. Future large-scale prospective studies are needed to confirm these results.N Engl J Med. Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range.

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