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It trimethoprim used fors acne the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Efficacy for this organism in this organ system was studied in fewer than 10 infections. Polymyxin B and Trimethoprim Ophthalmic: MedlinePlus Drug ... The information is not trimethoprim used for acne to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else.

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Trimethoprim
Clinical data
Pronunciation/ t r aɪ ˈ m ɛ θ ə p r ɪ m /
Trade namesProloprim, Monotrim, Triprim, others
AHFS/Drugs.comMonograph
MedlinePlusa684025
License dataUS   FDA: Trimethoprim
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationOral
ATC codeJ01EA01 ( WHO ) QJ51EA01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability90–100%
Protein binding44%
Metabolismhepatic
Elimination half-life8-12 hours
ExcretionUrine (50–60%), faeces (4%)
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Controlled studies in pregnant women show no evidence of fetal risk.New York: Pergamon Press. 7.

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