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Ursodeoxycholic acid
Clinical data
Trade namesActigall, Udcasid, others
AHFS/Drugs.comMonograph
MedlinePlusa699047
License dataUS  DailyMed:  19396, US   FDA: Ursodiol
Pregnancy categoryAU: B3 US: B (No risk in non-human studies)
Routes of administrationoral
ATC codeA05AA02 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only

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In some situations, this improvement in liver enzyme levels has been accompanied by improvements in symptoms, liver histology and long term adverse outcomes of these diseases cirrhosis, end stage liver disease Ursodiol was approved for dissolution of gallstones in 1987 and as a therapy of primary biliary cirrhosis in 1996.

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Drug Class: Gastrointestinal Agents, Bile Acids References updated: 25 September 2017 Abbreviations used: FXR, farnesoid X receptor; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; OCA, obeticholic acid; PBC, primary biliary cirrhosis cholangitis Review of hepatotoxicity published in 1999; mentions that ursodiol is an isomer of chenodiol and poses is ursodeoxycholic acid good for fatty liver demonstrable risk of hepatic injury in humans, although it causes liver injury in rabbits and rhesus monkeys Sharkey KA, Wallace JL.

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In general, other symptoms of overdose are unlikely because the absorption of UDCA decreases with increasing dose and therefore more is excreted with the faeces. No specific counter-measures are necessary and the consequences of diarrhoea should be treated symptomatically with restoration of fluid and electrolyte balance.o 1/100 Rare.

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