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Warfarin
Clinical data
Pronunciation/ ˈ w ɔːr f ər ɪ n /
Trade namesCoumadin, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682277
License dataUS   FDA: Warfarin
Pregnancy categoryAU: D US: X (Contraindicated)
Routes of administrationBy mouth or intravenous
ATC codeB01AA03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability79-100% (by mouth) [3]
Protein binding99% [2]
MetabolismLiver: CYP2C9, 2C19, 2C8, 2C18, 1A2 and 3A4 [2]
Elimination half-life1 week (active half-life is 20-60 hours) [2]
ExcretionKidney (92%) [2]

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Warfarin information
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Warfarin all other namesaldocumar, anasmol, arefarin, choice, circuvit, coumadine, coumafene, cumar, farevan, fargem, farin, hemeran, jantoven, kovar, lawarin, marevan, marfarin, marivarin, martefarin, orfarin, panwarfin, simarc, uniwarfin, warafin, waran, warfant, warfarex, warfarina, warfarine, warfarinum, warfilone, warfin, warin, warlin
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For recurrent VTE not associated with subtherapeutic warfarin anticoagulation we suggest either increasing the target INR range or switching to an alternative anticoagulant.Biochem Biophys Res Comm.

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A risk of hepatitis and other viral diseases is associated with the use of blood warfarin rats poison canadian tire PCC and activated Factor VII are also associated with an increased risk of thrombosis. Therefore, these preparations should be used only in exceptional or life-threatening warfarin rat poison canadian tire episodes Crystalline warfarin sodium occurs as a white, odorless, crystalline powder that is discolored by light.Call your doctor right away if you have pain in your toes and they look purple or dark in color.

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Prothrombin time tests and regular visits to physician or clinic are needed to monitor therapy.INR range, 2 to 3 for all treatment durations.

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It is also more expensive than lab-based tests, but can offer significant advantages for patients with limited mobility and other obstacles to regular laboratory monitoring.Hoffman RS, Howland MA, Lewin NA, Nelson LS, Goldfrank LR, eds.

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