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Promethazine
Clinical data
Trade namesPhenergan, many others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682284
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, rectal, IV, IM, topical
ATC codeD04AA10 ( WHO ) R06AD02 ( WHO )
Legal status
Legal statusAU: S3 (Pharmacist only) CA : OTC UK: P (Pharmacy medicines) (POM when injection), US: ℞-only South Africa: S5 IV S2 Oral
Pharmacokinetic data
Bioavailability88% absorbed but after first-pass metabolism reduced to 25% absolute bioavailability [2]
Protein binding93%
MetabolismLiver glucuronidation and sulfoxidation
Elimination half-life16–19 hours [2] [3]
ExcretionKidney and biliary

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  1. Allersoothe 25 mg
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  11. Farganesse 25 mg
  12. Fenazil 25 mg
  13. Fenazin 25 mg
  14. Fenazine 25 mg
  15. Fenergan 25 mg
  16. Frinova 25 mg
  17. Hiberna 25 mg
  18. Histabil 25 mg
  19. Histaloc 25 mg
  20. Histantil 25 mg
  21. Histazin 25 mg
  22. Histerzin 25 mg
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