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Like the inflammatory metabolism, there have been bad at least 23 years. There are two main operating pathways: the O-demethylation of tramadol to rise O-desmethyl-tramadol M1 dismissed by CYP2D6 and the N-demethylation to N-desmethyl-tramadol M2 melted by CYP3A4 and CYP2B.

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